Hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is a genetic disorder caused by defective genes that lead to abnormal blood vessel development. This results in telangiectasias and arteriovenous malformations (AVMs) in internal organs (such as the lungs and liver), making individuals prone to spontaneous bleeding or bleeding from minor trauma. This disease commonly affects young and middle-aged adults. The main symptoms include skin telangiectasias and recurrent bleeding from mucous membranes and the gastrointestinal tract.