Epidermolysis bullosa

Epidermolysis bullosa (EB) is a chronic, non-inflammatory bullous disease characterized by the skin and mucous membranes being susceptible to mechanical damage and forming blisters. It is characterized by significant mechanical fragility of epithelial tissue, with blisters and erosions appearing after minor trauma. This disease can be divided into the following two types: Hereditary epidermolysis bullosa: Commonly occurs in infancy. According to the location of blister formation under a transmission electron microscope, it is divided into three types: Epidermolysis bullosa simplex (EBS): Blisters or cleavages are located within the epidermis. It usually occurs within 1 year of age, and the prognosis is generally good. Junctional epidermolysis bullosa (JEB): Blisters are located within the lamina lucida of the basement membrane zone. It is clinically rare, has a poor prognosis, and most patients die within 2 years of age. Dystrophic epidermolysis bullosa (DEB): Also known as dermolytic epidermolysis bullosa, blisters or cleavages occur below the lamina densa of the basement membrane zone. The prognosis is poor. Acquired epidermolysis bullosa (EBA): An autoimmune disease. It commonly occurs in elderly individuals.