Progressive spinal muscular atrophy

Progressive spinal muscular atrophy, also known as spinal muscular atrophy, is a common group of autosomal recessive genetic diseases characterized by progressive muscle weakness and atrophy due to degeneration of anterior horn cells of the spinal cord. Based on the age of onset and the extent of the lesion, the disease can be divided into 4 types: Types I to III are called childhood-onset progressive spinal muscular atrophy, which are autosomal recessive genetic diseases and are the most common fatal genetic diseases in infancy. Onset at 20 to 30 years of age or older is classified as Type IV, which can present with different inheritance patterns such as autosomal recessive, dominant, and X-linked recessive.