Pulmonary alveolar proteinosis

Pulmonary alveolar proteinosis (PAP) is a disease characterized by the deposition of phospholipid-rich proteinaceous material in the alveoli and terminal bronchioles, leading to dyspnea. This disease is clinically rare, commonly affecting middle-aged individuals between 30 and 50 years old, with a higher incidence in males than females. The main symptoms include exertional dyspnea, cough, and fatigue.