Childhood Langerhans cell histiocytosis

Langerhans cell histiocytosis, abbreviated as LCH, was formerly known as histiocytosis-X, Letterer-Siwe disease, Hand-Schüller-Christian disease, and diffuse reticuloendothelial proliferation, but these names are now obsolete. The medical term "eosinophilic granuloma" is sometimes used to describe the pathology of individual lesions, particularly isolated osteolytic lesions. This is a very rare disease in which various tissues and organs of the body are infiltrated by dendritic cells called "histiocytes" after onset, leading to impaired function of these organs. The most commonly infiltrated organ is the bone, manifesting as osteolytic bone disease. In addition, the skin, lymph nodes, lungs, thymus, liver, spleen, bone marrow, and central nervous system can also be infiltrated by histiocytes, leading to dysfunction. This disease can occur at any age but is most common in children aged 1 to 3 years.