Hereditary spherocytosis

Hereditary spherocytosis (HS) is a familial genetic disorder caused by a congenital defect in the red blood cell membrane, leading to the formation of spherical red blood cells that are easily destroyed, resulting in hemolysis. There are currently no precise statistics on the incidence of this disease. In northern regions, HS is the most common hereditary hemolytic anemia. The main symptoms include anemia, jaundice of the skin and sclera, and splenomegaly. Cholelithiasis is common, and clinical manifestations vary significantly among different patients.