Von Willebrand disease

Von Willebrand disease can be divided into two categories: Hereditary von Willebrand disease: A common inherited bleeding disorder. It is caused by a deficiency of a substance called "von Willebrand factor (vWF)" in the body, leading to impaired hemostasis. (Von Willebrand factor: Synthesized under the control of a gene on chromosome 12. It plays an important role in hemostasis and coagulation.) It can be classified into the following types: Type 1: Primarily a quantitative deficiency of vWF, meaning vWF levels are low. Symptoms are relatively mild, mainly involving mucocutaneous bleeding. Type 2: A qualitative deficiency of vWF, with slightly more severe symptoms. Type 3: Complete absence of vWF, with the most severe bleeding manifestations, which can include spontaneous joint and muscle bleeding, and hematomas. Acquired von Willebrand disease: A bleeding disorder that generally arises secondary to other diseases. Clinical manifestations are very similar to hereditary von Willebrand disease. The main symptoms include mucocutaneous bleeding and intractable postoperative bleeding. In severe cases, spontaneous joint and muscle bleeding may occur.