Malignant mastocytosis

Malignant mastocytosis is a rare disease associated with immune function. It is caused by an increase in the number of mast cells in the skin, bone marrow, and other internal organs, which release substances that can trigger allergic symptoms and inflammatory reactions. The main symptoms include skin lesions and systemic manifestations. Skin lesions include erythema, urticaria, wheals, indurated nodules, generalized flushing accompanied by itching. Systemic manifestations include digestive symptoms such as abdominal pain, nausea, and vomiting.