Primary lateral sclerosis
Primary lateral sclerosis
Primary lateral sclerosis is a motor neuron disease primarily affecting the corticospinal tracts. It is characterized by spastic paraplegia with normal sensation. It typically has an insidious onset in middle age (50-60 years old) and progresses slowly. It manifests as progressive spastic paraplegia or quadriplegia, with subsequent involvement of the upper limbs and pharyngeal muscles.
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