Infectious DiseasesHepatology
Hepatitis B serologic markers
Hepatitis B serologic markers
Hepatitis B serologic markers, also known as "Hepatitis B five items" or "Hepatitis B two pairs and a half," are the most commonly used serum markers in China for detecting Hepatitis B virus (HBV) infection. They include:
Hepatitis B surface antigen (HBsAg)
Hepatitis B surface antibody (anti-HBs)
Hepatitis B e antigen (HBeAg)
Hepatitis B e antibody (anti-HBe)
Hepatitis B core antibody (anti-HBc)
These five indicators, in different combinations, represent different clinical significances. Common results are as follows:
1, 3 positive, others negative: Indicates that the patient is in the early stage of acute Hepatitis B infection, with active viral replication and strong infectivity.
1, 3, 5 positive, others negative: Formerly known as "big three positive," indicates that the patient has acute or chronic Hepatitis B, with active viral replication and strong infectivity.
1, 5 positive, others negative: Indicates that the patient has acute Hepatitis B or is a chronic Hepatitis B virus carrier, with weakened viral replication and weak infectivity.
1, 4, 5 positive, others negative: Formerly known as "small three positive," indicates that the patient has acute or chronic Hepatitis B, with weakened viral replication and relatively weak infectivity.
5 positive, others negative: Indicates that the patient may have had a past Hepatitis B virus infection, but anti-HBs was not detected or produced; or the patient is in the recovery phase, with HBsAg having disappeared and anti-HBs not yet appearing; or the patient is an asymptomatic HBsAg carrier.
4, 5 positive, others negative: Indicates that the patient is in the recovery phase of Hepatitis B virus infection.
2, 5 positive, others negative: Indicates that the patient is in the recovery phase of Hepatitis B virus infection and has acquired immunity.
1, 2, 3, 5 positive, 4 negative: Indicates re-infection with different subtypes of Hepatitis B virus.
1 positive, others negative: Indicates that Hepatitis B virus DNA is in the integration phase, in the latent period, and is infectious.
2 positive, others negative: Indicates that the patient has acquired immunity after illness or vaccination.
3, 5 positive, others negative: Is the result of HBsAg variation.
1, 2, 4 positive, others negative: Is the result of HBsAg and HBeAg variation.
2, 4, 5 positive, others negative: Indicates that the patient is in the recovery phase of Hepatitis B and has acquired immunity.
All five negative: Indicates that the patient has not been infected with Hepatitis B virus and does not have protective antibodies.
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