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2553 conditionsPage 251 of 284

Internal MedicineNeurology

Stiff-person syndrome

Stiff person syndrome (SPS) is a rare, chronic autoimmune disorder of the central nervous system with an unknown etiology, characterized by excessive contraction of the trunk and lower limb muscles, accompanied by painful muscle spasms. This disease is more common in adults, with rare onset in childhood, and the incidence in women is approximately twice that in men. The main manifestations of this disease are severe stiffness and spasms of the trunk and limbs (especially the legs), accompanied by significant pain and impaired mobility.

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Internal MedicineNeurology

Progressive spinal muscular atrophy

Progressive spinal muscular atrophy, also known as spinal muscular atrophy, is a common group of autosomal recessive genetic diseases characterized by progressive muscle weakness and atrophy due to degeneration of anterior horn cells of the spinal cord. Based on the age of onset and the extent of the lesion, the disease can be divided into 4 types: Types I to III are called childhood-onset progressive spinal muscular atrophy, which are autosomal recessive genetic diseases and are the most common fatal genetic diseases in infancy. Onset at 20 to 30 years of age or older is classified as Type IV, which can present with different inheritance patterns such as autosomal recessive, dominant, and X-linked recessive.

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Disease Database

Stiff-person syndrome

Progressive spinal muscular atrophy

Progressive bulbar palsy

Menstrual migraine

Carotid steal syndrome

Muscle contracture

Myotonic dystrophy

Brown-Séquard syndrome

Spinal cord infarction